Boronic acid, (phenylmethyl)- (9CI)
Benzylboronic acid
CAS: 4463-42-7
Molecular Formula: C7H9BO2
Boronic acid, (phenylmethyl)- (9CI) - Names and Identifiers
| Name | Benzylboronic acid |
| Synonyms | Benzylboronic acid BENZYLBORONIC ACID Phenylmethylboronic acid B-(Phenylmethyl)-boronic acid Boronicacid, B-(phenylMethyl)- α-Tolueneboronic acid(7CI,8CI) boronic acid, B-(phenylmethyl)- Boronic acid, (phenylmethyl)- (9CI) |
| CAS | 4463-42-7 |
| InChI | InChI=1/C7H9BO2/c9-8(10)6-7-4-2-1-3-5-7/h1-5,9-10H,6H2 |
Boronic acid, (phenylmethyl)- (9CI) - Physico-chemical Properties
| Molecular Formula | C7H9BO2 |
| Molar Mass | 135.96 |
| Density | 1.108±0.06 g/cm3(Predicted) |
| Melting Point | 195-215 °C |
| Boling Point | 296.5±33.0 °C(Predicted) |
| Flash Point | 133.1°C |
| Vapor Presure | 0.000644mmHg at 25°C |
| pKa | 9.55±0.43(Predicted) |
| Storage Condition | -20℃ |
| Refractive Index | 1.526 |
Boronic acid, (phenylmethyl)- (9CI) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| Hazard Note | Irritant |
Boronic acid, (phenylmethyl)- (9CI) - Introduction
Benzylboronic acid is an organic compound with the chemical formula C7H8BO2. The following is an introduction to the nature, use, preparation and safety information of Benzylboronic acid:
1. nature:
-Appearance: Benzylboronic acid is a white crystalline solid.
-Solubility: It can be dissolved in water and organic solvents (such as ethanol, dimethylformamide, etc.).
-Stability: relatively stable at room temperature.
2. use:
-Organic synthesis: Benzylboronic acid is an important organic synthesis intermediate, which is widely used in copper-catalyzed Suzuki reaction and other cross-coupling reactions.
-Drug research: It also plays an important role in drug research, used for the synthesis of drug candidate compounds and drug library screening.
-Coordination chemistry: Benzylboronic acid forms stable complexes with metals, which can be applied to coordination chemistry research and catalytic reactions.
3. Preparation method:
-Industrial method: Benzylboronic acid is usually obtained by the reaction of benzyl magnesium bromide and trichloroborane.
-Laboratory preparation method: Benzylboronic acid can be prepared by reacting benzyl lithium with trichloroborane in the laboratory.
4. Safety Information:
- Benzylboronic acid is generally considered to be a relatively safe compound, but should be handled with caution.
-Avoid contact with skin, eyes and mucous membranes during operation, and wear protective gloves and glasses if necessary.
-If accidentally swallowed or inhaled, seek medical attention immediately.
1. nature:
-Appearance: Benzylboronic acid is a white crystalline solid.
-Solubility: It can be dissolved in water and organic solvents (such as ethanol, dimethylformamide, etc.).
-Stability: relatively stable at room temperature.
2. use:
-Organic synthesis: Benzylboronic acid is an important organic synthesis intermediate, which is widely used in copper-catalyzed Suzuki reaction and other cross-coupling reactions.
-Drug research: It also plays an important role in drug research, used for the synthesis of drug candidate compounds and drug library screening.
-Coordination chemistry: Benzylboronic acid forms stable complexes with metals, which can be applied to coordination chemistry research and catalytic reactions.
3. Preparation method:
-Industrial method: Benzylboronic acid is usually obtained by the reaction of benzyl magnesium bromide and trichloroborane.
-Laboratory preparation method: Benzylboronic acid can be prepared by reacting benzyl lithium with trichloroborane in the laboratory.
4. Safety Information:
- Benzylboronic acid is generally considered to be a relatively safe compound, but should be handled with caution.
-Avoid contact with skin, eyes and mucous membranes during operation, and wear protective gloves and glasses if necessary.
-If accidentally swallowed or inhaled, seek medical attention immediately.
Last Update：2024-04-09 02:00:46
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CAS: 4463-42-7
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CAS: 4463-42-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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